ALLOBLAST® – Allogeneic Fibroblast from the Foreskin

ALLOBLAST® belongs to Tissue Biotechnology Stem Cell, Biobank and Tissue Engineering Center and is the first proprietary allogeneic fibroblast cell product in Turkey .

ALLOBLAST® is an allogeneic application method based on the injection of fibroblast cells obtained from the newborn's foreskin to the area where the person needs it by multiplying with bioengineering techniques in a high-tech laboratory environment. ALLOBLAST® is an allogeneic fibroblast product developed and made available for the first time in Turkey by scientists at the DOKU BIOTECHNOLOGY Stem Cell, Biobank and Tissue Engineering Center.

ALLOBLAST ® is not a stem cell product. Stem cells; They take descriptive names such as mesenchymal stem cell, hematopoietic stem cell, embryonic stem cell. Today, experimentally applied stem cells for tissue regeneration and treatment of metabolic diseases are known as “mesenchymal stem cells”. For the production of mesenchymal stem cells, a GMP laboratory approved by the Ministry of Health and a production process of at least 4-6 weeks (in autologous products) are required. Apart from that, products that are promoted, applied and claimed to be stem cells, unfortunately, cannot be considered as stem cells. In addition, there is no quality analysis of these products.

In cellular applications; The preparation of a product specific to you using your own cell or tissue does not mean that it is safe or effective! Even your own tissues must be processed, produced, passed through quality analyzes in facilities with tissue/cell processing authority, that is, in GMP approved laboratories, and given to you for application after their compliance with national and international quality standards is approved.

Where to Obtain ALLOBLAST® Product? What is Reliability?

ALLOBLAST® is obtained from the foreskin of newborn boys. It can be thought that one out of every 500 foreskin on average can fulfill the criteria of being a healthy donor. Because; Not every newborn is considered a suitable donor for ALLOBLAST production. In addition, thanks to the high-tech production techniques of our center, ALLOBLAST can be produced for 1000s of people from the foreskin of only 1 suitable donor. Before the reliability of the ALLOBLAST source is approved, clinical product production processes are not started, and the tissues are destroyed. Records are kept to be shared with the Ministry of Health.

All evaluations and reliability studies are performed by our center based on EMA (European Medicines Agency) and FDA (American Food Agency) donor criteria, including additional analyzes. This process proceeds in line with the permission of the Ministry of Health and the authorization given to our center.
Informed consent is obtained from the family who donated the foreskin to our center and from the doctor who performed the procedure.
From the last 4 months of pregnancy, my baby is followed up to the first 3 days after birth.
21 separate parameters, including the mother and father, are examined that will not pose a risk for the donor.
The history of the mother and father is evaluated.
Sterility, Serology and PCR tests are performed to detect viruses, bacteria, fungi, etc. It is documented that it is clean in terms of infections and recorded to be stored in our center and shared with the Ministry of Health.
It is tested that the foreskin can produce ALLOBLAST in sufficient quality and quantity.
Alloblast cells are produced on an industrial scale and banked accordingly, with specific, validated techniques and GMP grade components considering allogeneic use, not according to standard cord blood banking systems.

It consists of pure neonatal fibroblast cells that are healthy, young and resistant to adverse metabolic stresses.

It is one of the cellular therapy methods approved by the FDA and EMA (European Medicines Agency) in the world.
It provides 4 times higher level of collagen production compared to fibroblasts in their 40s.(1)
Thanks to long telomeres, a permanent and longer regenerative effect is targeted.
GMP-approved stem cells with the permission of the Ministry of Health are produced, tested and approved in a biobank and tissue engineering center.
It can be applied to the dermal areas of the whole body, including the eye area and genital area.
It can be applied the next day only if requested 24 hours in advance.
The recommended application is a single session, but multiple sessions can be performed with the approval of the doctor.
There is no need for serology testing, biopsy and blood collection, so no time is wasted with production processes that take at least 4 weeks.
Does not cause allergy or immune reaction. (2)
It does not contain Botox or any filler components, it is a pure cell solution. (3)
It does not create an appearance that may cause a change in mimics or facial expression.

(1) Expressed in comparison to autologous fibroblasts based on laboratory testing.
(2) Neonatal fibroblasts do not form an immune response when they can be obtained from certain donors (selection) at certain stages and produced under certain production and quality criteria. (3) Pure neonatal fibroblasts contain bioactive molecules produced by cells and isotonic solution as carrier.

Usage Areas of ALLOBLAST ® Application

To support the removal of wrinkles on the skin,
Supporting the lightening of spots and dark areas,
To support the closure of chronic wounds (diabetes, pressure, venous ulcer, etc.) that do not close,
To support facial rejuvenation applications that can be done with mesotherapy,
To support the filling of pits (atrophic scars) formed after ailments such as acne or chickenpox,
To support the treatment of cavities and scars due to burns, previous surgery or trauma,
To support the stimulation of hair follicles in cases of baldness,
There are scientific or clinical studies that it can be used to support the prevention of gingival recession in dentistry.